Social Media and Leibniz’ Monadology Artificial Experience I

The Yale-Düsseldorf Working Group on Philosophy and Media juxtaposes thought figures from the history of philosophy with concrete media-technical ensembles under the rubric ‘Artificial Experience’. More specifically, it studies the artificiality of human and non-human experience as media. The hypothesis is that historical philosophical figures offer different perspectives on traditional as well as current media-technical objects. Following Gilbert Simondon’s theory, the group also hopes to uncover specific modes of experience embedded in certain media-technical ensembles, modes which have remained hidden because the better thought figure has not yet been tested. This workshop will juxtapose Leibniz’s ‘monad’ — understood as an atomistic and highly perspectival account of experience — with current media technologies (for example, social media). The workshop is divided into two sessions. The first is a collaborative, in-depth reading of the Monadology and related texts and letters, asking questions such as: what forms of human and non-human experience can be observed there? Can this be understood as a mode of media or artificial experience? What roles do historical media play in Leibniz, the window, the mirror, the city, etc.? The second session will connect the figure of the monad with concrete media technologies proposed by participants themselves. What dimension of experience can be brought to light in the chosen media technology, if it is linked with Leibniz’s monadic thinking? Two further workshops organized by Martin Doll and Paul North on thought figures from Kant and Husserl will follow in 2023.Social Media and Leibniz’ Monadology Artificial Experience I, workshop, ICI Berlin, 5–6 October 2022 <https://doi.org/10.25620/e221005

Geister versammeln:Vorwort

Bereits zu Beginn seiner Abhandlung »Das Unheimliche« (1919) weist Sigmund Freud darauf hin, dass »dies Wort nicht immer in einem scharf zu bestimmenden Sinne gebraucht wird«. Entsprechend charakterisiert sich für Freud das Unheimliche durch eine Vielzahl an schwer zu fassenden Eigenschaften: Es bezeichnet eine seltsame Nähe zwischen Wissen und Nichtwissen, erscheint als etwas Vertrautes in fremder Gestalt oder als etwas Fremdes mit vertrauten Eigenschaften. Diese Unfassbarkeit und Definitionsresistenz führt Freud implizit darauf zurück, dass das Unheimliche als »abseits liegendes« Thema vom ästhetischen Fachdiskurs weitgehend vernachlässigt wurde.Martin Doll und Rupert Gaderer, »Geister versammeln: Vorwort«, in Phantasmata: Techniken des Unheimlichen, hg. v. Martin Doll, Rupert Gaderer, Fabio Camilletti und Jan Niklas Howe, Cultural Inquiry, 3 (Wien: Turia + Kant, 2011), S. 9–17 <https://doi.org/10.25620/ci-03_01

Medienwissenschaft und Kapitalismuskritik

Nachdem ›Kritik‹ während der vergangenen Jahrzehnte in vielen geistes- und kulturwissenschaftlichen Kreisen eher verschmäht wurde, erlebt sie gegenwärtig auch in der Medienwissenschaft wieder einen Aufschwung. Gerade das in Verruf geratene Projekt einer Gesellschaftskritik scheint seit der Finanzkrise von 2007 wieder an akademischer Attraktivität zu gewinnen. Dabei liegt die gedankliche Verbindung von Medienwissenschaft und Kapitalismuskritik nahe, schließt man damit doch an zwei dominante Selbstbeschreibungen der westlichen Gesellschaften an: die der Medien- oder Informationsgesellschaft einerseits und die einer kapitalistischen oder marktwirtschaftlichen Gesellschaft andererseits. Insofern scheint ein Dialog zwischen der Erforschung von Medien und der Erforschung des Kapitalismus geradezu zwingend. Das vorliegende Heft versammelt eine Reihe von Texten, die weniger konkrete Fallstudien zu einzelnen Medien und Medienpraktiken, sondern vornehmlich theoriebezogene Diskussionsbeiträge sind, welche das diskursive Feld der Medienwissenschaft und Medienforschung ausloten und auf die virulenten Fragen der Kapitalismuskritik hin befragen

Effect of telehealth on use of secondary care and mortality: findings from the Whole System Demonstrator cluster randomised trial

Objective To assess the effect of home based telehealth interventions on the use of secondary healthcare and mortality

Electric mobility concepts and their significance for the economy, society and the environment. Summary

Electromobility is currently fuelling hopes worldwide for a more sustainable development of the transport sector. The TAB report analyses ecological, economic and social aspects of electromobility for Germany and compares them with those of conventional automobiles. The ecological balance is particularly in favour of electromobility when low- or zero-CO2 energy sources are used, because in addition to greenhouse gases, other pollutant emissions are also significantly reduced. The economic analysis examines economic efficiency, implications for the automotive value chain and jobs, and the supply of critical raw materials. With a future stronger diffusion of electromobility in Germany, slightly positive effects on the employment situation and the development of GDP are expected. The social implications are examined on the basis of acceptance, user behaviour, traffic noise and accidents. The report shows that a positive user acceptance can be achieved with a wider range of models while complying with common quality and comfort standards as well as extended test possibilities, but also by reducing acquisition costs, a wider range of user-friendly mobility and business models and, last but not least, a transparent positive environmental balance. On the basis of the analyses, critical aspects and potentials of electric mobility are discussed, leading to policy-relevant conclusions and options for action

Cosmic Ray particle production

The status of some popular models to simulate hadronic and nuclear interactions at Cosmic Ray energies is reviewed. The models predict the rise of all the hadronic and nuclear cross sections with energy and a smooth (logarithmic) rise of average multiplicities, rapidity plateaus and average transverse momenta with the energy. The importance is stressed to put more effort into the models and especially a better understanding of the minijet component at the highest energies. Likewise, experimental data on particle production are needed at the highest possible energies, to guide the models.Comment: 13 pages, LATEX, espcrc2.sty, 21 figures included as ps file

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species constituting a major cellular defense mechanism against agents that induce oxidative stress. The MnSOD promoter contains an activator protein-2 (AP-2) binding site that modifies transcription of MnSOD. Mutations have been identified in the proximal region of the promoter in human tumor cell lines. One of these mutations (-102C>T) has been shown to change the binding pattern of AP-2 leading to a reduction in transcriptional activity. The aim of our study was to develop a method to identify and determine the frequency of this (-102C>T) polymorphism in human tissues. RESULTS: A new TaqMan allelic discrimination genotype method was successfully applied to genomic DNA samples derived from blood, buccal swabs, snap frozen tissue and paraffin blocks. The polymorphism was shown to be in Hardy-Weinberg Equilibrium in an evaluation of 130 Caucasians from Warsaw, Poland: 44 (33.8%) were heterozygous and 6 (4.6%) were homozygous for -102T. CONCLUSION: This report represents the first description of the MnSOD -102C>T polymorphism in human subjects by a novel Taqman allelic discrimination assay. This method should enable molecular epidemiological studies to evaluate possible associations of this polymorphism with malignancies and other diseases related to reactive oxygen species

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress. A genetic polymorphism in the mitochondrial targeting sequence of this gene has been associated with increased cancer risk and survival in breast cancer. This base pair transition (-9 T > C) leads to a valine to alanine amino acid change in the mitochondrial targeting sequence. A polymorphism has also been identified in the proximal region of the promoter (-102 C>T) that alters the recognition sequence of the AP-2 transcription factor, leading to a reduction in transcriptional activity. The aim of our study was to investigate possible associations of the -102 C>T polymorphism with overall and relapse-free breast cancer survival in a hospital-based case-only study. MATERIALS AND METHODS: The relationship between the MnSOD -102 C>T polymorphism and survival was examined in a cohort of 291 women who received chemotherapy and/or radiotherapy for incident breast cancer. The MnSOD -102 C>T genotype was determined using a TaqMan allele discrimination assay. Patient survival was evaluated according to the MnSOD genotype using Kaplan–Meier survival functions. Hazard ratios were calculated from adjusted Cox proportional hazards modeling. All statistical tests were two-sided. RESULTS: In an evaluation of all women, there was a borderline significant reduction in recurrence-free survival with either one or both variant alleles (CT + TT) when compared with patients with wild-type alleles (CC) (odds ratio, 0.65; 95% confidence interval, 0.42–1.01). When the analysis was restricted to patients receiving radiation therapy, there was a significant reduction in relapse-free survival in women who were heterozygous for the MnSOD -102 genotype (relative risk, 0.40; 95% confidence interval, 0.18–0.86). Similarly, when the homozygous and heterozygous variant genotypes were combined, there remained a significant reduction in relapse-free survival in this group (hazard ratio, 0.42; 95% confidence interval, 0.20–0.87). CONCLUSION: The MnSOD -102 variant allele appears to be associated with an improved recurrence-free survival in all patients, and more dramatically in subjects who received adjuvant radiation therapy

Ab initio correlation approach to a ferric wheel-like molecular cluster

We present an ab initio study of electronic correlation effects in a molecular cluster derived from the hexanuclear ferric wheel [LiFe6(OCH3)12-(dbm)6]PF6. The electronic and magnetic properties of this cluster have been studied with all-electron Hartree-Fock, full-potential density functional calculations and multi-reference second-order perturbation theory. For different levels of correlation, a detailed study of the impact of the electronic correlation on the exchange parameter was feasible. As the main result, we found that the influence of the bridge oxygen atoms on the exchange parameter is less intense than the influence of the apical ligand groups, which is due to the geometry of the cluster. With respect to the cluster model approach, the experimental value of the exchange parameter was affirmed.Comment: to be published in EPJ